The fundamental group of \(X\) at \(x_0\) is \[\pi_1(X, x_0) \;:=\; \bigl\{[\gamma] \mid \gamma \text{ is a loop based at } x_0\bigr\}\] equipped with the group operation of concatenation: \[[\gamma] \cdot [\delta] := [\gamma * \delta], \qquad (\gamma * \delta)(s) := \begin{cases} \gamma(2s) & s \in [0,\tfrac{1}{2}] \\ \delta(2s-1) & s \in [\tfrac{1}{2},1] \end{cases}\] The identity element is the class of the constant loop \([c_{x_0}]\), and the inverse of \([\gamma]\) is \([\bar\gamma]\) where \(\bar\gamma(s) := \gamma(1-s)\).
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ONT released its first commercial product in 2015: a handheld machine called the MinION that retailed for just $1000, a fraction of the price of most sequencers. Subsequent releases include more traditional benchtop sequencers such as the PromethION and GridION.
security and the progenitor of an important line of cryptographic algorithms.